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Any changes would require either: Comprehensive clinical development demonstrating safety and efficacy Substantial changes in federal drug policy The scientific community continues to see value in the mechanismpreclinical research continuesbut commercial therapeutic development remains stalled

Peters et al

To this end, several ubiquitin ligases have been harnessed for targeted protein degradation (TPD), yet structural data on their ternary complexes remain scarce, limiting insight into the molecular basis of these interactions

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